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Example: ~3050% of East Asians have ALDH2 deficiency, leading to red flushing and higher cancer risk

146,147 Similarly, interactions between commensal microbes and immune barriers (e.g., gastrointestinal mucosa and urethra) have been formerly identified in diverse tissues

Moore, Thamavit, and Bannasch 1996)

Given that ferroptosis induction through either GPX4 inhibition (RSL3) or cystine depletion represents the two principal experimental paradigms in ferroptosis research, our comprehensive data establish selenomethionine as a universal ferroptosis suppressor with consistent efficacy across different induction mechanisms

At 8 weeks of age, doxycycline was removed from the diet (mice were placed on normal chow, ad libitum feeding) to induce MYC expression and tumorigenesis