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It can also occur in those dogs and cats with exocrine pancreatic insufficiency (EPI) or senior dogs or cats

[63] Physicians Guide to Oral Iron Supplements

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Activation of mania/hypomania has also been reported in a small proportion of patients with Major Affective Disorder treated with other marketed drugs effective in the treatment of Major Depressive Disorder [see Use in Specific Populations (8.4)]

Rare conditions like autoimmune lymphoproliferative syndrome (ALPS) have been linked to these changes, although overall evidence is limited 9