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However, lethargy constitutes a more profound manifestation of illness-associated symptoms, characterized by profound drowsiness, extreme lethargy, and cognitive dullness (7)

These include 5HT 4 R agonists (Prucalopride and TAK 954), vagus nerve stimulation of the ENSmacrophage nAChR cholinergic pathway, acupuncture, herbal medications, peripheral acting opioid antagonists (Alvimopen, Methlnaltexone, Naldemedine), anti-bloating/flatulence drugs (Simethiocone), a ghreline prokinetic agonist (Ulimovelin), drinking coffee, and nicotine chewing gum