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Folate insufficiency was one of these three variables that had the most impact on the serum tHcy levels, followed by MTHFR C677T and vitamin B12 deficiency (in decreasing order of impact) [48]

In HeLa cells, the Ag-NP-hydrogel exposure activated JAK-STAT signaling pathway by upregulating JAK-STAT cascade-related gene, thereby inducing toxicity (Xu et al., 2012)

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