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10.7150/ijbs.57825 188 WuD.WangX.ZhouR.YangL.CederbaumA

SAG has demonstrated efficacy in replenishing intracellular GSH in cultured fibroblasts from patients with genetic glutathione synthetase deficiency a condition where the de novo synthesis pathway is non-functional

However, recent studies suggest that combining lactate-targeting methods, including MCT4 inhibitors, with immunotherapy may offer new treatment options