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CrossRef Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in -Cells through the Activation of GPR40-PLC-IP3 Pathway Ximei Shen, Beibei Fan, Xin Hu, Liufen Luo, Yuanli Yan, Liyong Yang Journal of Diabetes Research.2019

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Both MMF and fumarate are believed to be responsible for the primary therapeutic effects of DMF through activation and inhibition of the transcription factors, Nrf2 (35, 36) and Nf-B (37), respectively