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In the 2025 Physician Fee Schedule proposed rule, we also acknowledged that, while this proposal would represent significant progress toward rationalizing attribution for the broader range of Advanced APMs, our continued analysis suggested that there may be more work to be done in this area

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Moreover, increasing evidence suggests the role of impaired folate metabolism in neurodegenerative processes [20, 66], underscoring its importance in maintaining neurological function

6.3 NADPH oxidase activation and oxidative burst Memory loss is a key characteristic of Alzheimer's disease (AD), a neurodegenerative condition caused by a complex pathological process that involves the overproduction of reactive oxygen species (ROS) (104)