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However, it is now understood that NLRP3 is expressed and activated across a broad range of cell types, including epithelial cells, endothelial cells, fibroblasts, hepatocytes, adipocytes, cardiomyocytes, skeletal muscle cells, neutrophils, platelets, T-helper cells, cytotoxic T cells, hematopoietic and mesenchymal stem cells, keratinocytes, and neurons (Vandanmagsar et al., 2011

Regarding ionotropic glutamate receptors (iGluRs), Na + influx of Na + and outflow of K + efflux increase the extracellular K + concentration, promote presynaptic depolarization of the presynaptic terminal to increase the secretion of Glu, and Glu release, and enhance postsynaptic depolarization

Unlike 5-HT reuptake inhibitors (e.g., SSRIs, SNRI, and TCAs), these agents do not augment EPS induction, but alleviate antipsychotic-induced EPS, which is possibly by blocking 2 , 5-HT 2 and 5-HT 3 receptors ( Closing Remarks This article provides information on the safe usage of antipsychotics in adjunctive therapy for BPSD in patients with dementia

C., Osazuwa, E

Recognizing the limitations of single-target drugs such as antioxidants and neuroprotective agents in improving ND symptoms, there is a continued emphasis on developing new drugs or combination therapies to address multifactorial causes, potentially offering more effective treatments for this disease