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Elevated Ca 2+ levels in the cochlea may link to ROS production as well as triggering apoptotic and necrotic cell death pathways independent of ROS formation (Orrenius et al., 2003)

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In addition, two Phase II clinical trials assessed the tolerance and efficacy of Ramucirumab (IMC-3G3) and MEDI-575 anti-PDGFR antibodies (NCT00895180 and NCT01268566 respectively) in patients with recurrent glioblastoma multiforme