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Additionally, excessive NO can break the balance of intracellular redox and trigger inflammatory reactions, resulting in muscle tissue damage and atrophy (Kaminski and Andrade, 2001)

Blood serum of anonymous donors was obtained from West-Tallinn Central Hospital (Estonia) and the study approval was obtained from Tallinn Medical Research Ethics Committee

It is imperative to explore novel strategies aimed at reducing MMA levels, considering the limited efficacy of B12 supplementation revealed by our findings

Cellular redox homeostasis depends on the balance between the generation and elimination of ROS by several enzymes and antioxidants, and the imbalance of cellular redox homeostasis leads to oxidative stress, which imposes a substantial burden on cells [29, 30]

Avatrombopag (sNDA), July 24, 2025 Swedish Orphan Biovitrum AB FDA decision on avatrombopag for treatment of thrombocytopenia in pediatric patients one year and older with persistent or chronic immune thrombocytopenia