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An almost identical result (84) was found in a randomized, double-blind, placebo controlled study done by a group of French clinicians, who also noted that thyroxin treatment dramatically reduced the number of newly recognized nodules during follow-up

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(81) determined urine excretion of mercapturic acids of benzene and acrolein in cigarette smokers who received oral supplementation of PEITC, and observed a remarkably stronger effect of PEITC in subjects with GSTM1 and GSTT1- null genotype with a significant higher excretion than in those with a normal genotype (88)

Moreover, a systematic review and meta-analysis of observational studies demonstrated that blood levels of copper in patients with depression were higher than those of patients without depression, while there was no difference in copper content in the hair between the two groups, suggesting that copper levels in the blood may be more sensitive to pathological changes in patients compared to those in the hair (Harvey et al., 2009