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J Pharm Sci 97(12):510621

This effect was likely due to attenuation of spinogenesis promoted by HGF and Dihexa treatments since, without the antagonizing effect of Hinge, each agonist increased mini-AMPA frequencies (Figure 13 A-B and Figure 10) thus forming functional synaptic connections

They have to then be tested by an outside lab to make sure of purity, make sure that there's no endotoxins, things like that