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The Fc domain not only provides steric protection against proteolytic enzymes but may also reduce immunogenicity by minimizing the generation of anti-drug antibodies

doi: 10.1002/cncr.29737 5 GrovesTRFarrisRAndersonJEAlexanderTCKifferFCarterGet al

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The absolute bioavailability (F) of an oral formulation, for example, is calculated using the following dose-normalized equation: Factors Affecting Bioavailability Drug Properties: The intrinsic physicochemical properties of the drug are especially important