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VNS is a neuromodulation technique used clinically for several neurological diseases such as refractory epilepsy and depression

A designer fusion of IL-22 to an antibody (to extend half-life) is in trials for preventing acute graft-versus-host disease after bone marrow transplant, and conceptually could be used for gut protection in big surgeries like aortic aneurysm repair to reduce intestinal permeability and subsequent sepsis