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Methods Animal work Animal work was carried out with ethical approval from University of Glasgow under the Animal (Scientific Procedures) Act 1986 and the EU Directive 2010 (PPL 60/4181)

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To achieve optimal results, it is important to follow the recommended dosages for NAC and glutathione supplements, which can vary based on individual health needs

[117] also investigated the impaired immune response with age in relation to carotenoid intake (-carotene, lycopene, lutein), finding that age-related changes in immune markers such as higher serum IgA levels and altered lymphocyte subpopulations (increase in memory Th cells (CD4 + CD45RO+) and natural killer (NK) cells along with a decrease in nave Th cells (CD4 + CD45RA+) and B lymphocytes) and impaired neutrophil activity, which could be modulated by carotenoid intake, depended only marginally on dietary carotenoid depletion and repletion [117]

The decreased concentrations may be explained by the fact that the study participants were likely older than the subjects used to establish the laboratory norms