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Funding This study was supported by the National Natural Science Foundation of China to QZ (No.32270407) and the open fund of State Key Laboratory of Southwestern Chinese Medicine Resources (No.SCMR202103) and Natural Science Foundation of Sichuan (No.2022NSFSC0583) to JL

In addition, serum levels of the acid-labile subunit (ALS) and IGFBP-3 are important in maintaining circulating IGF-I (Ohlsson et al., Igfals knock-out mouse model (Ueki et al., 2000) and by Domen et al