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Barrett TJ, Hawkins CL (2012) Hypothiocyanous acid: benign or deadly

Critical depletion of GSH in mitochondria culminates in increased levels of ROS and RNS, mitochondrial dysfunction and subsequent ATP depletion, which are responsible for the shift from apoptosis towards necrosis and, therefore, inflammation

Whether these tissues (other than the liver) were capable of metabolizing acetone or whether the metabolites themselves were distributed to the tissues was unclear

Administration: Typically given as an intravenous injection to ensure maximum absorption

doi: 10.3389/fimmu.2023.1116084 130 ChenLZhouQFangXXuQZouYZhangJ.et al