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Kitamura et al., 2014)

The M1 phenotype is often associated with disease, resulting in production and secretion of pro-inflammatory cytokines (i.e., tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1), and IL-6), chemokines, and ROS to neutralize pathogens and increase cell recruitment to the site of inflammation

Another study found that AOD-9604 can promote the regeneration of cartilage tissue in vitro

Discussion The efficacy and safety of therapeutic agents are significantly influenced by individual patient variations, disease complexity, and drug metabolism

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