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Redox regulation in cancer stem cells

Tesofensine's dopaminergic and serotonergic activity complicates its use in populations with psychiatric histories

PARP-1 has been found to interact directly with the RBR-type E3 ubiquitin ligase RNF144A, which promotes PARP-1 self-ubiquitination and proteasome-mediated degradation (Zhang et al., 2017), indicating that E3 ligases can also regulate PARP-1 stability in reverse