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Drug safety sciences and the bottleneck in drug development

The disruption in signaling cascade due to ROS may cause activation of transcription factors like MAP kinase, activator protein (AP-1) and nuclear factor-B (NF-B) which is related to cell proliferation and apoptosis (Valko 2006)

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Intragastric and oral administration give detectable plasma levels for several hours in rodent studies, supported by the proline-rich sequence resisting cleavage by gastric proteases