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4.2 The rhoA/ROCK signaling pathway The RhoA/ROCK signaling pathway is integral to both the initial stages of AS, particularly endothelial cell dysfunction, and the later stages involving the formation and rupture of atherosclerotic plaques (65)

It has an anti-inflammatory property, partly for its role as a metabolic regulator

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The simultaneous upregulation of TIMP-1 and TIMP-2, the natural inhibitors of MMPs, suggests a regulatory influence of GHK-Cu on the balance between matrix synthesis and matrix degradation (Pickart et al., 2015)

(2022) reported that suckling lambs from ewes supplemented with 5% fresh grape pomace achieved meat shelf-life comparable to those receiving vitamin E, underscoring its viability as a natural antioxidant alternative