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Taken together with the findings that utilization of esketamine as an antidepressant increases LAC levels [59], the fact that the decrease in LAC levels in subjects with MDD is independent of psychotropic drug treatment raises the possibility that increasing LAC levels may be needed to induce antidepressant effects

To establish more rigorous scientific evidence, a randomized, double-blind, placebo-controlled study was published in the journal Dermatology and Therapy in 2014

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Lower brain 18F-fluorodeoxyglucose uptake but normal 11C-acetoacetate metabolism in mild Alzheimers disease dementia

Rats treated with TMAO have been shown to increase inflammatory markers and promote early atherosclerosis modifying lipid metabolism and biomarkers