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Perhaps, spatial specificity underlies generator specific functionality wherein extra-synaptic NMDA linked mitochondrial O 2 .- generation is neurodegenerative whereas NOX2 linked synaptic NMDA receptor linked O 2 .- is protective [83]

the first are highly proliferative cells found in the perivascular zone, and the second group is composed of quiescent cells found in the hypoxic regions, suggesting that the microenvironment could influence the metabolism of these cells (Brooks and Parrinello, 2011)

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