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Liu KX, Li C, Li YS, Yuan BL, Xu M, Xia Z

physiology 314 (4), L606-L616l616

(4) Inactivation of GPx4 alone is insufficient to induce ferroptosis in hepatocytes

Conclusion: This strategy combines CDT/PDT/gas therapy, enabling the synergistic cascade of NO/ROS/reactive nitrogen oxide species (RNOS) to promote tumor cell apoptosis and inhibit tumor growth, thereby achieving a cascading amplification of therapeutic effects and providing a treatment solution to overcome the inherent limitations of traditional photodynamic therapy