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Histidine residues can coordinate to the Ni 2+ ion by replacing the bound water molecules (indicated by red arrows)

doi:10.1016/j.xkme.2019.12.006 Watson RR, Schonlau F

Isoliquiritigenin inhibits non-small cell lung cancer progression via m 6 A/IGF2BP3-dependent TWIST1 mRNA stabilization

reported that PAL mutants of Arabidopsis were more sensitive to ultraviolet light than wild type plants but were more tolerant to drought [51]