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Overexpression of a lncRNA MEG3 reversed these, and decreased apoptosis through the activation of PI3K/AKT/mTOR pathway 50

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Thus, TRIP12-generated K29-linkage besides protecting itself from OTUD5-mediated deubiquitylation, also 1) facilitates UBR5-dependent assembly of K48-linked chains and 2) modestly protects K48-linkages from disassembly as forms of mixed/branched linkages