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Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis

Almeida AF, Borge GIA, Piskula M, et al

Fan MZ, Matthews JC, Etienne NMP, Stoll B, Lackeyram D, Burrin DG

Notably, many polyphenols also exhibit circadian activity e.g., resveratrol can activate the SIRT1 pathway which influences the clock, and quercetin can modulate clock gene expression in cells