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Rodent models have contributed significantly to our understanding of synaptic physiology, but growing evidence points to distinctive features of human neurons that are not fully captured in rodents 5 , making direct investigation in human cells essential for studying synaptic pathologies linked to cognitive decline

They are meant to help people with B12 deficiency

Conventional anti-folates such as aminopterin, pralatrexate, methotrexate (MTX), and pemetrexed (PMX) are the most prevalent types of DHFR inhibitors