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High Development Costs and Investment Risks The high costs linked with research, development, and clinical trials for senolytic drugs create financial risks for pharmaceutical companies

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Similarly, the population of HIV reservoir cells that constitutes the major barrier to a cure for AIDS is exquisitely redox sensitive and could be selectively targeted by Trx and GSH inhibitors

Activated microglia flood the lesion with TNF-, which in turn drives endothelial RIP1/RIP3/MLKL activation, disrupts the BSCB and amplifies leukocyte infiltration