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The authors also acknowledge financial support from the, National Key Research and Development Program of China (2021YFA0910700, 2018YFA0902701), Guangdong Science and Technology Department (2020B1212030004), Chinese Academy of Sciences Presidents International Fellowship Initiative (2021PB0019), Guangdong Provincial Basic and Applied Basic Research Fund Project (2020A1515010726) and Sanming Project of Medicine in Shenzhen (SZSM201911011)