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In addition, mechanisms such as disrupted RNA processing, mitochondrial dysfunction, protein dyshomeostasis, axonal transport disruption, and inflammation have been linked to the pathogenesis of the disease 3,4,5

Biochimica et Biophysica Acta.2012;1820:19011907

Moreover, NF-B can reduce the transcription of antioxidant molecules, such as GPX4, NQO1, and HMOX1, as well as participate in oxidative stress and induce ferroptosis 20