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Long-term safety considerations favor peptides with decades of topical use showing no concerning patterns, while Botox long-term effects remain incompletely understood with questions about muscle atrophy from chronic paralysis, antibody formation reducing effectiveness requiring dose escalation, and potential spreading effects from repeated treatments though definitive evidence proving harm remains limited

ii) mitochondrial impairment leading to ROS accumulation

Methods Enzymol 252:3853 Xiong CH, Xia YL, Zheng P, Wang CS (2013) Increasing oxidative stress tolerance and subculturing stability of Cordyceps militaris by overexpression of a glutathione peroxidase gene

Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11