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We also briefly address senescence in other immune cell types

It occurs when mast cellsimmune cells responsible for allergic responsesbecome overactive and release excessive amounts of histamine and other inflammatory mediators

Furthermore, alcohol and certain medications such as phenobarbital, phenytoin (Dilantin), carbamazepine (Tegretol) (anti-seizure medications), or isoniazid (INH, Nydrazid, Laniazid) - (anti-tuberculosis drug) can significantly increase the damage

Moustafa AA, Chakravarthy S, Phillips JR, Gupta A, Keri S, Polner B, Frank MJ, Jahanshahi M (2016) Motor symptoms in Parkinsons disease: a unified framework