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The fluorescence of TPE-DCV thus solely depends on the yielded GSH in this enzymatic reaction

82 While the mechanism is not fully understood, PD1/PDL1 immunotherapy and the subsequent cytotoxic tumor destruction are thought to induce a proinflammatory state that could stimulate melanocyte activity

Otherwise, primary damage stimulates a pathway that leads to ROS accumulation as secondary damage

Proliferation assay DOHH2 cells were kept in RPMI Medium 1640 (Gibco, Cat# 11875-119) supplemented with 10% Fetal Bovine Serum (Sigma, Cat# F2442), at 37 C, 5% CO 2 in a humidified incubator

Tumor heterogeneity and the intricate tumor microenvironment further complicate the efficacy of PCD-based nanotherapies