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By favorably influencing the folate/methionine cycle and restricting methionine metabolism, MOTS-c induces a shift in cellular priorities from growth toward maintenance

Oral delivery is the most effective for treating gastrointestinal issues

doi:10.5114/reum.2016.64911 Hfling DB, Chavantes MC, Juliano AG, et al

Calculations with the model show that blood concentrations do not necessarily reflect intracellular concentrations of metabolites

However, legal challenges have suspended any enforcement against compounding these (and other) peptides.36 Thats not to say that you cant get them legally, but that a particular clinician may be reluctant to prescribe them