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System info: X570 ASUS TUF Gaming Motherboard Ryzen 3800x Overclocked to 4.45Ghz (stable) MSI VENTUS 3X GeForce RTX 3080 16GB of Samsung B die ram 3800Mhz Corsair CX750M Power supply ASUS TUF 1080p 280hz monitor I get a constant 400 max fps in the training room but in an actual game I get around 200-300 on average even with low settings

As the MID domain undergoes little change in the transition to the TDMD conformation, we propose that these interactions serve as anchor points to help position the AGOmiRNAtrigger complex in an orientation suitable for the sensor domain of the opposite protomer to recognize trigger-induced conformational changes in the N and PAZ domains, and the trigger itself

Lombardo L, Foti M, Ruggia O, Chiecchio A

Activated ERK translocates to the nucleus where it phosphorylates transcription factors regulating proliferation and differentiation genes

FLAG-tagged FUS/TLS and HA-tagged SMN were expressed in HeLa cells using DNA transfection, extracts were prepared, FUS/TLS-containing complexes were recovered with FLAG antibody and finally any co-purified SMN was detected with an HA antibody