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Since the discovery of FSP1, more and more GPX4-independent ferroptosis pathways have been discovered in various physiological and pathological processes Drugs targeting GPX4-independent ferroptosis pathway may become a new direction for the treatment of diseases

Selecting the appropriate method or a combination of methods is crucial for accurately assessing antioxidant activity and for evaluating the potential applications of antioxidants in food preservation, pharmaceuticals, or as health-enhancing agents

A significant reduction in total mitochondrial BAX, comprising loosely attached and inserted forms, was observed following B-017 treatment (Fig