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Mesquida M, Victoria Hernndez M, Lloren V, Pelegrn L, Espinosa G, Dick AD et al

To measure sleep in fruit flies, she used an infrared-based Drosophila activity-monitoring system

This finding suggests that the insertion of the octanoyl group into cavity II not only contributes to the binding of the ligand, but also helps to orient the N-terminus of ghrelin to cavity I, which is critical in receptor activation