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Lastly, off-target effects and systemic consequences are potential therapeutic adverse effects that need to be considered, especially since the mitochondria are found throughout the entire body and both the mitochondria and microbiota have effects on other systems, through the gut-brain axis, immune system, and metabolism, to name a few (Flint, 2020)

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These studies independently confirmed that the majority of tumors harbor readily detectable somatic mutations in their mitochondrial DNA