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For instance, Salvianolic acid B was shown to attenuate paraquat-induced pulmonary fibrosis by restoring the Nrf2/NOX4 redox balance, where Nrf2 activation suppressed NOX4 expression and downstream TGF-1/Smad3 signaling ( S

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Moreover, hydroxyl radicals generated from the reaction between free ferrous iron and hydrogen peroxide can oxidize PUFAs by capturing hydrogen atoms at the diallyl site of PUFAs, representing an enzyme-independent autoxidation[29]

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Katturajan R, Sabina EP (2021) Joint inflammation: insights of osteoarthritis, gouty and rheumatoid arthritis and its prevalence, mechanism, medications and remedies