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2 Overview of the vagus nerve and its role in gastrointestinal disease The vagus nerve is a mixed nerve with 20% efferent and 80% afferent fibers: Afferent fibers carry information from various parts of the body to the brain

Lithium generally reduces excitatory neurotransmission from dopamine and glutamate and increases inhibitory neurotransmission from GABA [72]

Fruits and vegetables provide anthocyanins and carotenoids, some of which can cross the bloodbrain barrier or act through their metabolites to improve cerebral perfusion and activate endogenous antioxidant systems (163, 164)

The color of the blood may be used to assess both the presence and severity of methemoglobinemia (figure below with different shades of red)

18 ChaiJ.WuQ.ShiozakiE.SrinivasulaS