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AGEs may cause vascular dysfunction by making cross-bonds between extracellular matrix proteins (elastin and collagen), which leads to blood vessel stiffness, heart fibrosis, and diastolic dysfunction 12

Stewart S, Prince M, Bassendine M, Hudson M, James O, Jones D, et al

10.1016/j.apsb.2023.08.008 210 YooJ.JeongI.-K.AhnK.-J.ChungH.-Y.HwangY.-C

Gore & Associates: Speaking and Teaching, Thomas Reiberger: Nothing to Disclose, Tim Hendrikx: Nothing to Disclose 1541 SINGLE-CELL RNA SEQUENCING ANALYSIS REVEALS SPECIFIC CELL SUBPOPULATIONS IN ALCOHOL-ASSOCIATED HEPATITIS CHARACTERIZED BY INFLAMMATORY, ANGIOGENIC AND FIBROGENIC PROFILE Elisa Pose 1 Alicia Martnez 2 Aina Rill-Hinarejos 3 Jordi Gratacs Gins 1 Silvia Ario 2 Martina Prez 1 Ana Rubio 2 Celia Martnez-Snchez 2 Ramon Bataller 1 Pere Gines 1 Elisabetta Mereu 3 MAR COLL 2 , 1 Liver Unit, Hospital Clnic Barcelona - Institut d'Investigacions Biomdiques August Pi i Sunyer, 2 Institut d'Investigacions Biomdiques August Pi i Sunyer, 3 Josep Carreras Leukemia Research Institute Background: The phenotypic alterations of the different cell types through Alcohol-associated liver disease (ALD) progression are largely unknown