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In HCC, tumor-derived soluble substances, including hyaluronan fragments, activate neutrophil autophagy through Erk1/2, p38, and NF-B signaling pathways, therefore extending neutrophil longevity, maintaining pro-metastatic factors such as MMP9 and oncostatin M, and facilitating tumor growth (178)

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RABGAP1 KO affects the processing of exogenously expressed APP in HeLa cells To assess the role of RABGAP1 in the processing of APP, a transient RABGAP1 CRISPR knockout (KO) was generated in Cas9 HeLa cells stably expressing HaloTag-APP-mNeonGreen (Fig