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Thus, novel intervention strategies, such as treatment using antioxidants, metabolic rescue of autolysosomal degradation, and repurposing of conventional drugs, are possible options to counteract or fine-tune the current treatment for SLE (152)

Govindaiah G, Kang YJ, Lewis HES, Chung L, Clement EM, Greenfield LJ Jr, et al

Intratracheal delivery of GrDEVs loaded with aly-miR396a-5p to mice inhibited coronavirus-induced lung inflammation (reducing IL-6, TNF-, and immune cell infiltration), impeded viral replication via the miRNAs cross-kingdom gene-silencing effect, and reduced lung pathology (edema, hemorrhage) while improving oxygenation compared to controls [217]

Consistent with this concept, an intervention trial with 15 g of glycine daily during 3 months lowered HbA 1c levels in people with diabetes (Cruz et al., 2008), while acute ingestion of glycine together with an oral glucose bolus lowered glucose excursions (Gannon et al., 2002)

As a functional measure of endothelial health, even modest increases in flow-mediated dilation (FMD) are associated with a lower risk of future cardiovascular events