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Patients who experience persistent palpitations beyond 8 weeks at a stable dose should undergo formal cardiac evaluation, including ECG and Holter monitoring, to rule out atrial fibrillation or other arrhythmias that GLP-1 therapy may have unmasked rather than caused

EGR-1 is a "master switch" gene that is rapidly activated by various stimuli, including growth factors and mechanical stress

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For research protocols where precise timing of cognitive testing or behavioral assays matters, this delay must be factored into the experimental timeline

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