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Stress management Chronic psychological stress activates the hypothalamic-pituitary-adrenal (HPA) axis, producing cortisol that initially suppresses inflammation but eventually leads to cortisol resistance and a paradoxical increase in inflammatory signaling

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PMID: 34445382

Rader DJ, Mann WA, Cain W, Kraft HG, Usher D, Zech LA, Hoeg JM, Davignon J, Lupien P, Grossman M, et al