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Age and Demographic Considerations Clinical trials for both compounds have primarily enrolled adults aged 18-75 with specific metabolic profiles

428 The secondary bile acids produced by the intestinal microbiota directly act on the transcriptional activity of the CLOCK gene through the BMAL1/CLOCK transcription factor complex, driving the CR expression of downstream metabolism-related genes (such as those involved in energy homeostasis), 429 thereby regulating sleep and cognitive functions

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