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It has been suggested that frataxin is involved in the synthesis of iron-sulfur clusters, metabolism of heme, regulation of oxidative phosphorylation and mitochondrial bioenergetics amongst others (Moreno-Cermeo et al., 2010

Upon expert review, 20% of initial visits could have been avoided, of which 33% deemed avoidable with an urgent visit in hepatology, urgent paracentesis (24%), improved medical management at home (23%) and/or non-emergent weekend/holiday services (16%)

Seladelpar, a novel delpar (selective PPAR-delta agonist), demonstrated therapeutic efficacy in the phase 3 clinical trial RESPONSE

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Nevertheless, lifestyle modification poses considerable psychological challenges for many patients