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Rather than being a pharmaceutical development, this tripeptide occurs naturally in human blood plasma, with concentrations around 200 ng/mL at age 20 that decline to approximately 80 ng/mL by age 60

GIP receptor activation in adipose tissue influences lipid storage and mobilization, and in the brain, it contributes to appetite regulation through mechanisms that complement GLP-1 signaling

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The plasma metabolome analysis revealed distinct metabolite signatures in IF-P and CR groups, with the convergence of multiple metabolic pathways