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[ 440 ] BACH1 exerts a significant function to SCD pathogenesis, and some small molecule drugs (hydroxyurea, ASP8731, and HPPD) can treat SCD via BACH1 inhibition

As for vascular growth, which is highly correlated with tumor development, bilirubin inhibits ERK activity in damaged blood vessels, and because ERK activation is associated with the mitogenic stimulation-induced cyclin D1 expression (102, 103), the reduction of ERK activity caused by bilirubin may be responsible for the down-regulation of cyclinD1 by bilirubin after arterial injury

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10.1016/j.steroids.2019.108425 122 JiangC